What is Lucentis?

Lucentis is the trade name for ranibizumab, a monoclonal antibody fragment based on the larger molecule bevacizumab – which has the trade name Avastin. Both of these drugs are relatively new and represent a new class of therapeutic tools that block a molecule in the body that stimulates inflammation. Vascular endothelial growth factor A (VEGF-A) has many different physiological effects and is very useful because it stimulates the repair of tissues that have been damaged or injured. The trouble with VEGF-A is that it carries on working even when the circumstances mean that it does more harm than good.
In the eye, for example, retinal diseases that develop in older people cause the eye tissues to respond by becoming inflamed. This happens in diseases such as age related macular degeneration, retinal vein occlusion and the diabetic retinopathy – the eye disease that develops in some diabetics. As the layers of the retina become inflamed, local build up of fluid causes swelling, which disrupts the delicate photoreceptor cells that give us the ability to see. Sudden and serious vision loss is common, even when this fluid build up is just starting.
Anti-angiogenesis Research
The research efforts that led to the development of Lucentis and Avastin centred on looking at the molecular events that occur when tissue becomes inflamed, and at the processes that set off the growth of new blood vessels. Many tumours produce high levels of VEGF-A and this speeds up new blood vessel growth, giving the fledgling tumour an excellent blood supply so that its growth can go into overdrive.Inflammation in the back of the eye often leads to new blood vessel growth –a process known medically as choroidal neovascularisation – which means new (neo) blood vessel growth (vascularisation) in the choroid (the network of blood vessels that nourish the photoreceptors in the retina. This happens because the tissues are short of oxygen and the response of the body is to try to get a new supply of blood there as quickly as possible. Unfortunately, these blood vessels grow very haphazardly, smashing through the retina and destroying vision.
Lucentis and Retinal Disease
While bevacizumab has been studied in many clinical trials of different cancers, eye research has concentrated on the smaller anti-VEGF molecule ranibizumab. Lucentis has been developed for injection directly into the eye, where it can work to damp down inflammation in the retina, without having too much effect in the rest of the body. VEGF-A is vital for tissue repair and blocking it generally causes a lot of unwanted side effects. This is more acceptable in cancer treatment, where the treatment might mean the difference between life and death, but is not acceptable for an eye disease.Lucentis has now been approved for the treatment of age related macular degeneration and for the inflammation that follows retinal vein occlusion. Injections are given to people at the first sign that they are developing swelling in the retina, and these are repeated once a month to keep inflammation and also new blood vessel growth to a minimum.
Does Lucentis Work?
No treatment is a miracle cure and retinal disease causes damage that is irreversible. Once the nerve cells that connect the retina with the optic nerve have been lost, they can never be repaired or replaced. Studies in hundreds of people before Lucentis was approved, and results from probably thousands of people treated since show that the drug does slow down vision loss. Over a two year period, nine in every ten people with retinal diseases experienced an improvement or at least a stabilisation of their eyesight when treated with Lucentis. Four out of ten reported quite a substantial improvement in vision – they could read an extra three lines on the optician’s chart.Having the treatment every month can be done as in an outpatient clinic, and although its a bit uncomfortable, most people don’t find it too bad. A local anaesthetic is used, and the injection only takes a few seconds. For people who respond well, Lucentis is a valuable treatment that can prevent them losing their sight and it gives them a much better quality of life.
- What Do Intravitreal Injections Treat?
- Types of Retinal Laser Treatment
- What is Ozurdex?
- Angiogenesis Inhibitors and the Eye
- Telescopic Eye Implants Help Treat Macular Degeneration
- Lasek and Lasik Eye Surgery: What is the Difference?
- What Are Intravitreal Implants?
- Photodynamic Therapy for Opthalmic Conditions
- Cataract Removal Surgery
- What a Cornea Transplant Involves
- Using Drops and Ointments for Your Eyes
- The Pros and Cons of Laser Eye Surgery
- What is Laser Eye Surgery?
Re: What is Vitrectomy Surgery?
I had vitrectomy 4 weeks ago. The surgery was not well done as apparently bleeding occurred. The hole did not close despite having…
Re: Glasses or Contacts?
I need a eye exam and new glasses it's been since 2013/ I have no income I lost my boyfriend last September and I've been homeless ever…
Re: Eyewear for the Partially Sighted
This extract from your text is not clear and the grammar is poor- and the letters in the validation box are mixed…
Re: Eye Cancer Symptoms
I have yellow in both eyes lools like 2 dots. But looks like its makin the white part of my eye yellow whats wrong with me
Re: Are my Glasses Affecting my Eyes?
Hi, Please can anyone give advice on wearing varifocals. After a short while I develop a severe ache in my left eye and…
Re: Are my Glasses Affecting my Eyes?
On wearing my new varifocals, I am finding that my left eyeball hurts so much it feels like it will explode after 15…
Re: What is the Cause of my Itchy Eye?
I have One and only One itchy eye that has been going on 24/7 for 5 weeks.Eye is not swollen vision not affected. Eye doc…
Re: Contact Lens Trials Explained
Hi, We wanted to get in touch with you to increase traffic on your website. Please reply to this email so we can send you free…
Re: What Are Photoreceptors?
I have a 10 year old grandson who was diagnosed at apx 2 with cone and rod dystrophy eye disease. Please help with any treatment…
Re: Driving and Eyesight
Danny6520 - Your Question:Hi,I am only 16, but soon I will be 17and I am hoping to drive. However I have a few problems. Firstly, I am…